منابع مشابه
P-glycoprotein and tumor progression.
Development of resistance to chemotherapy is a hallmark of many advanced human cancers. The molecular basis of clinical resistance is not well understood. Over the past 15 years, a number of different molecular mechanisms of resistance to anticancer drugs have been identified in many cell lines. One mechanism involves the increased expression of the plasma membrane P-glycoprotein (Pgp), which i...
متن کاملP-Glycoprotein Expression during Tumor Progression in the Rat Liver1
P-Glycoprotein (Pgp) has been shown to mediate multidrug resis tance in tumor cell lines. Overexpression of Pgp has been detected in clinical cancer samples of many histolÃ3gica!types. The basis and bio logical significance of such increases in Pgp expression are not well understood. In this study, the expression of Pgp during stepwise pro gression to rat liver cancer was examined to investigat...
متن کاملP-glycoprotein expression during tumor progression in the rat liver.
P-Glycoprotein (Pgp) has been shown to mediate multidrug resistance in tumor cell lines. Overexpression of Pgp has been detected in clinical cancer samples of many histological types. The basis and biological significance of such increases in Pgp expression are not well understood. In this study, the expression of Pgp during stepwise progression to rat liver cancer was examined to investigate t...
متن کاملThyroid Hormone and P-Glycoprotein in Tumor Cells
P-glycoprotein (P-gp; multidrug resistance pump 1, MDR1; ABCB1) is a plasma membrane efflux pump that when activated in cancer cells exports chemotherapeutic agents. Transcription of the P-gp gene (MDR1) and activity of the P-gp protein are known to be affected by thyroid hormone. A cell surface receptor for thyroid hormone on integrin αvβ3 also binds tetraiodothyroacetic acid (tetrac), a deriv...
متن کاملBromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells.
One of the most important causes of anticancer treatment failure is the development of multidrug resistance (MDR). The main characteristics of tumor cells displaying the MDR phenomena are cross-resistance to structurally unrelated cytotoxic drugs having different mechanisms of action and the overexpression of the MDR1 gene, which encodes a transmembrane glycoprotein named P-glycoprotein (P-gp)....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1994
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/86.11.814